|
 Diabetes
is a ntered disease to human being. People all over the
world believe that diabetes is a syndrome caused by lack
of insulin or the malfunction of the target cell of insulin
which result in the disturbance of metabolism of glucose,
protain, ancommonly and frequently encoud lipid. Owing to
the prolonged pathologic change of diabetes and improper
treatment, it leads into the chronic progressive pathologic
changes of many tissues and organs such as the eye, kidney,
heart, skin, nerve and blood vessel, etc.
According to the common view of medical scientists all over
the world, the reason that causes diabetes is not completely
known. Therefore thee is no satisfying medicine to cure
the disease up till now. Those west medicines like Sulfurea
and Biguanide drugs their series perform well in improving
the symptoms but no breakthrough in complete therapy.
It
is an everlasting subject for seeking and research the ideal
medicine for diabetes. Considering medicine, instructed
by the modern west medicine theory, combined with Chinese
and west medicine, we created a new method to cure diabetes
clinically, and thus invented pure Chinese medicine YU XIAO
SAN 8805, YU XIAO SAN 8806 and their series to prevent and
cure diabetes.
Since
1984, the study of "Chinese medicine human organic regeneration
and rejuvenation" has been started. The primitive test was
aiming at diabetics and complication of renal failure. We
tried to improve the renal regeneration, but resulted in
finding out the miracle that the formula can decrease the
blood glucose for diabetes then transferred to the subject
of diabetes. Since then, clinical observation and laboratory
study from multiangle had been started surrounding the formation
and efficiency pancreas, islets of pancreas, and insulin,
the formation and efficacy of pancreatic glucagon, and their
secretion, transform, efficacy, degradation, regulation
etc.
These
jobs include: " The decrease of blood glucose test Report
of YU XIA SAN 8804 and YU XIAO SAN 8805" provided by Pharmacological
Office of Beijing Chinese Medicine Science Study Institute.
(See attachment I) " Acute Toxicity test report of YU XIAO
SAN 8805" (See attachment II), and other 58 cases small
scale clinical application, (See attachment III), and another
100 cases, 500 cases that is big scale clinical observation.
(See attachment IV). It was used formally in our hospital
and 48 hospitals and scientific institutes all over China
in 1987. (See attachment V), until 1995, was used by 200,000
people all over the world. The total efficacy to NIDDM (Non
insulin dependent) patients is 85%, and 27% for IDDM (Insulin
dependent) patients.
The
following is a 10618 case report of diabetics who used YU
XIAO SAN 8805 during the period of February 1992 to October
1992.
I.
Choosing Cases
1.
Diabetics are confirmed diagnosis under the diagnosis standard
of diabetes published by WHO.
2. Clinical fasting blood glucose is 7.8 mmol/L (140mg.dl)
or above, glucose in urine is positive and with obvious
symptoms.
3. Blood glucose could not be controlled within the normal
range after using Chinese and west medicine for over 3 months.
(equal to term 2)
4. Blood glucose is abnormal for or over 3 months without
using any Chinese or west medicine.
II. General Information
Among
10618 cases under investigation and therapy, 5318 cases
were provided by our hospital (1268 In-patients' cases,
4050 outpatients' cases), 5300 cases were provided by other
corporate medical units.
1. Sex: 5204 males, 5414 females. The ratio between male
and female is 1:1.04
2. Age: 1610 cases were under 40 years old, 15.16%: 7116
cases between 40-60 yeas old, 67.02%; 1892 cases over 60
years old, 17.82%.
3. Duration of illness: 2548 cases were between 3 months
or more and within one year, 24%; 3398 cases of them were
between one to five years, 32%; 2442 cases were between
5 to 10 years, 23%; 2230 cases were over 10 years, 21%.
4. Patient conditions: Fasting blood glucose of 4791 cases
were7.8 to 11.1mmol/L (140-200 mg/dl), 42.25%; fasting blood
glucose of 1341 cases were 16.7 mmol/L (300mg/dl), 12.63%.
5. The state of using medicine: 1236 cases were confirmed
Insulin dependent, which was 11.64% of the total, 136 of
them used insulin more than 50 units every day, which was
11% of insulin therapy. 9832 cases were non-insulin dependent,
which was 88.36% of the total. 3046 cases had taken sulfarea
drugs, which was 28.69% of the total. 2395 cases had taken
biguanide drugs, which was 22.56% of the total; 3198 cases
had taken both drugs, which was 30.12; 342 cases without
taking any drugs. 3.22%; 401 cases had taken other Chinese
medicine such as YU
QUAN WAN, which was 3.78%.
III.
Observation Method
1.
Self-comparison method. Observe 2 courses of treatment continuously,
each course 2 months.
2. Take YU XIAO SAN 8805, 8 tablets each time, 350mg/tablet,
4 times/day, one hour before dinner and sleep, with water.
3. For patients using of original antihyperglycemic drugs
at the beginning of using YU XIAO SAN 8805, there is no
dosage change of the insulin injection and oral antihyperglycemic
that had already taken. After taking YU XIAO SAN 8805, fasting
blood glucose and blood glucose 2 hours after dinner recovered
to normal, then start reducing the original drugs (not include
YU XIAO SAN) one fourth of daily dosage, step by step per
week (reducing the dosage but not the times.) until the
zero. As for insulin dependent diabetics, reduced 2 units
each time step by step per week, till the zero. If during
the reduction of dosage, blood glucose and urine sugar rebounded,
just compensated what reduced until the flood glucose and
urine sugars reduced to the normal level and continued to
reduce the dosage. After taking YU XIAO SAN 8805 exclusively,
if the blood glucose test kept normal for the continuous
3 months, YU XIAO SAN 8805 could be stopped.
4. Buns Test, C-Ti, insulin release test, pancreatic glucagon,
sacharogenic hemoglobin, renal function, liver function,
blood rheology test, fasting blood glucose, blood glucose
2 hours after dinner and urine sugar quantity for 24 hours
tested at least once a month before and after taking YU
XIAO SAN 8805 for four months.
5. Under the condition of proper diet, moderate exercises,
avoiding angry, tiredness and hot, spicy food.
VI.
Judgment for treatment result:
A.
Clinical Recovery:
1. fasting blood glucose is <6.1mmol/L(110mg/dl), HbAlc<6.8%
2. Blood lipid is normal
3. 24 hour urine sugar quantity is<5g
4. Clinical symptoms are disappeared, complications are
healed
5. Insulin units, or oral drugs are stopped taking completely,
and maintain over 3 months.
B.
Obvious effect:
1. Fasting blood glucose is <7.8mmol/L(140mg.dl), HbAlc<8%
2. Blood lipid is reduced, cholesterol is <5.96mmol/L(230mg/dl)
triglyceride <1.47mmol/L(130mg/dl)
3. 24 hour urine sugar fixed quantity is <10g
4. Clinical symptoms and complications obviously reduced.
5. Insulin or oral drugs partially are stopped taking.
C.
Effect:
1. fasting glucose low 3.33mmol/L(60mg/dl), HbAlc<9%
2. Blood lipid is reduced, cholesterol<6.48mmol/L (250mg/dl),
triglyceride< 1.70mmol/L (150mg/dl)
3. Clinical symptoms and complications abate, or no development.
4. 24 hour urine sugar quantity is < 15g
5. No decrease of insulin units or oral drugs.
D. No Effect: All indexes have no
inclination of decrease.
V.
Treatment Result
1. 1878 cases healed, which is 17.69% of total; 2452 cases
were obvious effect, 23.09%; 3979 cases were effect, 37.47%;
23309 cases were no effect, 21.75%.
I
Treatment Result of 10616 cases of diabetics (NIDDM, IDDM)
|
Clinical
Healed |
Obvious
Effect |
Effect
|
No
effect |
| Cases |
1878
|
2452
|
3979 |
2309 |
| Percentage
|
17.69% |
23.09%
|
37.47%
|
21.75% |
2.
Of 5204 male cases, 921 cases got clinical recovery, which
is 17.70%; obvious effect 1201 cases, 23.08%; 1950 case's
effect, 37.47%; 1132 cases no effect, 21.75%. Of 5414 female
cases, 957 cases had clinical recovery, which is 17.68; 1251
case obvious effect, 23.11%; 2029 cases effect, 37.48%; 1177
case no effect, 21.74%.
II Relation between Sex and Curative Effect
|
Clinical
Healed |
Obvious
Effect |
Effect
|
No
effect |
| Male |
921(17.70%)
|
1201(23.08%)
|
1950(37.47%)
|
1132(21.75%) |
| Female |
957(17.68%)
|
1251(23.11%)
|
2029(37.47)
|
1177(21.74%) |
3. Among 2548 cases whose courses f the disease were more
than 3 months up to one year, 570 cases got clinical healed,
which is 22.37%; Obvious effect 667 cases, Effect 899 cases,
35.28%; No effect 412 cases, 16.17%. Among those between one
year and 5 years, there were 3398 cases, 672 cases were clinical
healed, which is 19.78%; 863 cases got obvious effect, which
is 25.40%; 1300 cases effect, 38.26%; 563 cases no effect,
16.57%. Among those between 5 year and 10 years, there were
2442 cases, in which 398 cases clinically recovered, which
is 16.30%; 539 cases obvious effect, 22.07%; 949 cases effect,
38.86%; 556 cases no effect, 22.77%. There were 2230 cases
whose course of disease were more than 10 years, among which
238 cases got clinically recovered, which is 0.67%; 383 cases
with obvious effect, 17.17%; 831 cases with effect, 37.26%;
778 cases with no effect, 34.89%.
III
Relation between Course of Disease and Curative Effect
|
Clinical
Healed |
Obvious
Effect |
Effect
|
No
effect |
| >1
year |
570(22.37%)
|
667(26.18%)
|
899(35.28%)
|
412(16.17%) |
| 1-5
years |
672(19.78%)
|
863
(25.40%) |
1300(38.26%)
|
563(16.57%) |
| 5-10
years |
398(16.30%)
|
539(22.07%)
|
949(38.86%)
|
556(22.77%) |
| >10
years |
238(10.67%)
|
383(17.17%)
|
831(37.26%)
|
778(34.89%) |
4.
Among 1236 IDDM cases, 84 were cured, 6.8%; 106 obvious
effect, 8.58%; 144 effect, 1165%; 902 no effect, 72.98%.
3046 NIDDM cases administered by sulfaurea medicine, 557
were cured, 18.29%; 736 obvious effect, 24.16%; 1478 effect,
48.52%; 275 no effect, 9.03. 2395 cases with Biguanide medicine,
575 were cured, 24.01%; 647 obvious effect, 27.01%; 936
effect, 39.08%; 237 no effect, 9.90%. 3198 cases combined
with two kinds of medicines, 476 were cured, 14.88%; 748
obvious effect, 23.39%; 1109 effect, 34.68%; 865 no effect,
27.05%. 401 cases administered by other Chinese herbs, 96
were cured, 23.94%; 125 obvious effect. 31.17%; 166 effect,
41.4%; 14 no effect, 3.49%. 342 without use any medicine,
90 were cured, 26.32%; 90 obvious effect, 26.32%; 146 effect,
42.69%; 16 no effect, 4.68%.
VI
Effect relation between Diabetes I And Diabetes II
|
Clinical
Healed |
Obvious
Effect |
Effect
|
No
effect |
Total
Effect |
| Type
I |
84(6.80%)
|
106(8.58%)
|
144(11.65%) |
902(72.98%)
|
27.02% |
| Type
II |
|
|
|
|
85.00% |
| Sulf
|
575(18.29%)
|
736(24.16%) |
1478(48.52%)
|
275(9.03%) |
|
| Bigu |
575(23.94%)
|
647(27.01%)
|
936(39.08%)
|
237(9.03%) |
|
| Chn
|
96(23.94%)
|
125(31.17%)
|
166(41.40%)
|
14(3.49%) |
|
| W/o
|
90(26.32%)
|
90(26.32%)
|
146(42.69%)
|
16(4.68%) |
|
*sulf-patients
oral sulfaurea medicine
bigu-patients oral Biguanide medicine
Chn-Patiients oral other Chinese medicine
5. IDDM: Among 136 cases who the daily dosage of Insulin
is over 50 units, 5 were cured, 3.68%; 7 obvious effect,
5.15%; 8 effect, 5.88%; 116 no effect, 85.29%.
V
|
Healed |
Obvious
Effect |
Effect
|
No
effect |
Total
effect |
|
5(3.68%) |
7(5.15%)
|
8(5.88%)
) |
116(85.29%)
|
14.71% |
6.
Changes of blood glucose, blood insulin and blood pancreatic
glucagon. Blood glucose and pancreatic glucagon reduced
significantly after the treatment. It proves "YU XIAO SAN
8805" can decrease blood glucose level obviously.
VI Comparison Blood Insulin, Glucose and glucagon and
glucagon before and after the treatment
| Glucose
(mmol/L) |
Insulin
(uu/ml) |
Glucagon
(Pg/ml) |
|
Before 13.41+-2.11 |
8.81+-1.51
|
133.59+-25.85 |
| After
7.51**+-0.83 |
10.20*+-2.03
|
82.41**+-21.31 |
| *p<0.05
**p<0.001 |
|
|
7. The
changes of blood lipid and blood rheology. Cholesterol,
triglyceride reduce clearly (p<0.001), Blood viscosity,
plasma viscosity, PCV, hemomcyte electrophoresis time reduce
greatly. (p<0.01), Blood sedimentation equation K go down
significantly. (p<0.01), Fibrinogen decrease. It indicates
blood viscosity low marvely.
VII Comparison blood lipid and blood rheology before
and after the treatment
|
Cholesterol |
Triglyceride |
Blood
viscosity |
Plasma
viscosity |
HET
|
PCV
|
Blood
sedimentation |
K
Fibrinogen |
|
|
mmol/L
|
mmol/L
|
ratio |
ratio |
mm/s
|
m%
|
ratio
|
g/u |
| Before |
6.52+-0.57
|
1.86+-0.15
|
4.90+-0.79
|
1.87+-0.15
|
19.74+- 0.88 |
47.64+-
0.83 |
43.72+-9.33
|
4.44+-0.29 |
| after
|
5.04+-0.39
|
1.13+-0.35
|
33.98+-0.66
|
1.64+-0.15
|
16.45+-
0.55 |
46.65+-
0.89 |
37.71+-7.56
|
4.26+-0.24 |
Note:
above data kindly provided by corporate units.
VI
CONCLUSION
The
results of clinic and Lab (animal test) research indicates:
1.
YU XIAO SAN 8805 can improve function of the pancreas, increase
secretion of insulin and decrease blood glucose. Meanwhile,
it can decrease blood lipid that is similar to the find
in the Lab. Of the Stanford University for YU XIAO SAN 8805.
2. The effective rate of YU XIAO SAN 8805 for IDDM is 27.02%,
in which 6.8% of patients who were followed for six months
at least are no longer use insulin. 8.85% patients' function
of the pancreas was improved with decreased dosage of insulin.
11.65% patients' symptoms had abated notably.
3. The effective rate of YU XIAO SAN 8805 for NIDDM is 85%.
Among the 8639 patients who took western medicines, 1608
patients stopped using western medicine, 18.61% in the total;
2131 patients reduce the dosage of western medicine, 24.67%;
3523 patients' symptoms had abated, 40.78%. Therefore, YU
XIAO SAN 8805 had effect on patients taking either Sulfured
or Biguanide, even patients who failed to react to western
medicines. It is clear to us that the mechanism of YU XIAO
SAN is different from the western medicine.
4. YU XIAO SAN 8805 can improve symptoms for those who took
western medicine (Sulfurea and Biguanide) without any effect.
The effect was no relation with sex and age but time of
the disease and degree of the complications.
5. YU XIAO SAN 8805 can increase ability of immunity. For
patients having antibody for insulin and daily usage of
insulin over 50 units, 33.68% patients were clinically cured,
5.15%
patients decreased the dosage of insulin and 5.88% patients
'blood sugars were lower'. The mechanism of this phenomenon
needs further study.
6. The effect of decreasing blood glucose and lipid of YU
XIAO SAN 8805 is superior to other Chinese medicine that
are currently use (for example, YU AUAN WAN is produced
in BEI JING and SICHUAN). If patients took decoction prescribed
by traditional Chinese theory based on YU XIAO SAN 8805
the effective rate reached to 95.96%. This is the symbol
that YU XIAO SAN 8805 should improve on the form and extraction.
7. On observing clinic, it is clear that YU XIAO SAN 8805
reduced blood lipid, decreased blood viscosity, promoted
blood circulation and abated and prevented symptoms of complications.
8. YU XIAO SAN 8805 can increase endurance for carbohydrate,
improve assimilation of liver glycogen and catabolism of
muscle glycogen. All of these become foundation to improve
symptoms of the diabetes.
9. The bile is a necessary composition for forming insulin.
YU XIAO SAN 8805 is composed of the herb which can stimulate
the secretion of the bile, then the increase the composition
for insulin is important during the course of reducing blood
sugar.
10. During analysis of the YU XIAO SAN 8805, the trace elements
had been found. The relation between trace elements and
herbs should be considered.
VII
DISCUSSION
YU XIAO SAN 8805 is composed of natural Chinese herbs. It
is invented by famous diabetes expert CHONG LIAN JIN based
on the theory of "organ regeneration" in traditional Chinese
medicine and "embryogenesis" in western medicine.
The
academic ideas of Dr. CHONG LIAN JIN are:
1. It is well know that the origin,
degree and prolong of the diabetes are depend on the secretion
status of the insulin and usage efficacy the insulin. At
present, oral drugs for diabetes in clinic are either to
increase secretion ability of insulin or to higher usage
efficacy of the insulin while there are lack of the drug
to combine the two functions in one. (Sometimes uses the
two drugs together). YU XIAO SAN 8805 is just combining
the two functions into one.
2. The islet is a tissue that secretes insulin. B cell in
the islet is a cell that can form insulin. To stimulate
B cells will increase insulin secretion and control the
blood glucose. But over-stimulation will drive B cell exhaustion.
In clinic many patients turn NIDDM to IDDM because the reason.
Thus only through stimulating B cell is not proper way to
correct blood sugar level. YU XIAO SAN 8805 is to improve
functions of liver and duodenum in order to accelerate the
metabolism of pancreatic tissue then activate living ability
of B cells and B cells will increase the secretion automatically.
3.
The secretion of the bile has the direct relation with the
product of insulin owing to the bile which is the one of
necessary composition for insulin synthesizing. This is
a key factor but it is not fully used by pharmacists. In
reference to the function of YU XIAO SAN 8805 is strengthened
by the herbs that can stimulate the bile in order to meet
the need of the insulin synthesizing.
4. To enhance tolerance of carbohydrate to the extreme extent
is the important content for treatment and preventing diabetes.
There s no perfect reliable western medicine in the whole
field. YU XIAO SAN 8805 that has strong aimed herbs plays
the advantage of Chinese medicine to enhance extensively
the tolerance of carbohydrate provided the best recovery
conditions for patients suffering from diabetes and helpful
function for B cell activating and regeneration.
5.
Pancreatic glucagon is recognized as an antagonist to insulin
all the time. For decreasing hyperglycema and increasing
secretion of insulin, moderating the abnormal antagonism
of pancreatic glucagon is also a unnegligible method for
treatment and preventing diabetes. Through the compound
effect by YU XIUAO SAN 8805 patients' pancreatic glucagon
is reduced and this result has not seen in other reports
yet.
6. The assimilation of hepatic glycogen and catabolism of
muscle glycogen are the very important aspect for treatment
and preventing diabetes. The herbs of improving the functions
contain a great Reito in the formula of YU XIAO SAN 8805.
7. The most herbs in the formula of YU XIAO SAN 8805 can
upgrade the ability of immunity by reports from several
Labs. For low ability of immunity of patients with diabetes
especially the low sensitivity and vagueness of the target
cells YU XIAO SAN 8805 has helpful and adjustment effect.
It can not been denied patients with diabetes treated by
YU XIAO SAN 8805 had stronger immunity along with decreasing
blood sugar.
8.
" Activating blood flow and removing blood stasis" is another
important rule for treatment and preventing diabetes that
inherits Chinese medical tradition and combines modern medical
theory of microcirculation The formula of YU XIAO SAN 8805
includes compositions of "activating blood flow and removing
blood stasis". The something should point out is that "during
translation of turning insulin factor into insulin" of YU
XIAO SAN 8805 plays some function. This is an interesting
information for further research.
9. The kidney as an organ consuming insulin greatly and
easestly attacked by diabetes should not be neglected in
time of treatment and preventing the disease development
in the kidney are quite significant. Currently western medicine
can not reach the point. What they only can do is by reducing
the blood glucose to prevent the complications. While under
the rules of Chinese medicine there are several ways to
tonifying the kidney. YU XIAO SAN 8805 collects of these
kind herbs to protect the kidney in any conditions. At least
it can reduce the deterioration of complication in the kidney.
Summarizing
above, the clinic significance of YU XIAO SAN 8805 is following:
It
is the first time pointing out in the world:
The regeneration of B cells in the islets, combining the
theories of "embryogenics" and " organ regeneration" of
Chinese medicine, changes the low secretion ability of B
cells in islets on diabetic pathologic phenomenon by Chinese
medicine.
It is the first time conforming in the world:
Through enhancing the tolerance to carbohydrate and reducing
the burning load of insulin, combining the theories of the
human function and "strengthening the body resistance to
eliminate pathogenic factors" of Chinese medicine, Chinese
medicine can improve the recovery conditions for the pathologic
islets in the pancreas.
It is the first time revealing in the world:
Combining the theories of endocrinology and "five evaluative
phases" of Chinese medicine, Chinese medicine can help the
course of turning the insulin factor into insulin.
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|
Yu
Xiao San (pronounced yoo-shee-ow-sahn) is a 100% natural herbal
product developed by 
Yu
Xiao San 8804 is another fine product invented by Dr. Chong Lian
Jin. It is also based on the Human Organ Restoration Theory of
Traditional Chinese Medicine. This theory combines modern science
and TCM in an exhaustive study. As a result, a health food
to prevent diabetes was invented.